INTEGRALL

INTEGRALL collects and organizes integron DNA sequences into a centralized database to support analysis of integron molecular arrangements, gene cassette content, and the distribution of antibiotic resistance genes.

Key Features:

• Text-based search: Provides text-based search functionality for querying integron sequences and annotations.
• Sequence repository: Houses over 4,800 integron sequences (version 1.2).
• Centralized database: Consolidates integron sequence data and nomenclature in a single database.
• Molecular context annotation: Contains curated information on integron molecular arrangements and genetic contexts, including gene cassettes.
• Advanced query capabilities: Enables advanced searches to analyze specific integron structures and associated gene cassettes.
• Curation: Curates integron sequences from multiple sources to maintain up-to-date and accurate records.
• Distribution tracking: Supports tracking the distribution and diversity of integrons across bacterial species and environments.

Scientific Applications:

• Microbial genetics: Analyzing integron-mediated gene cassette acquisition and expression in bacterial genomes.
• Evolution of resistance: Investigating the evolution and spread of antibiotic resistance genes carried by integrons.
• Environmental microbiology: Characterizing integron diversity and distribution in environmental samples.
• Surveillance: Tracking integron-associated resistance genes across bacterial species and environments for comparative studies.
• Comparative genomics: Comparing integron structures and gene cassette repertoires across isolates or species.

Methodology:

Curates integron sequences from various sources, organizes them systematically in a centralized database, and provides text-based search and advanced query capabilities for analysis.