INTEGRATE-Vis

INTEGRATE-Vis visualizes gene fusion products from sequencing data and infers transcript- and protein-level consequences, including novel protein formation and associated gene expression changes.

Key Features:

• Automated Annotation: Performs automated annotation of gene fusion candidates identified from sequencing data at both transcript and protein levels.
• Customizable Visualizations: Generates customizable graphics to depict fusion structures and associated transcript- and protein-level annotations across individual samples or patient cohorts.
• Transcript- and Protein-Level Analysis: Provides detailed transcript- and protein-level annotations to evaluate potential novel protein formation and consequences of fusion breakpoints.
• Expression Assessment: Evaluates gene expression changes associated with gene fusions within individual samples and across patient cohorts.

Scientific Applications:

• Cancer Genomics: Interprets gene fusion events to hypothesize functional impacts, including fusion-driven novel proteins and expression alterations.
• Disease Mechanism and Therapeutic Target Discovery: Supports generation of hypotheses about fusion-driven mechanisms and potential therapeutic targets through visualization and annotation of fusion events.

Methodology:

Processes sequencing data to identify gene fusion candidates, performs automated transcript- and protein-level annotation, and generates customizable visual representations of fusion events and associated expression patterns.