INTERFEROME

Interferome catalogs and analyzes genes regulated by types I, II, and III interferons (IFNs) to support studies of interferon-mediated gene regulation across infection, immunity, development, and cancer.

Key Features:

• Extensive Gene Collection: Compiles genes regulated by IFNs from high-throughput expression datasets of cells treated with these cytokines.
• Integrated Data and Annotation: Integrates detailed gene annotation and ontology information for contextual functional interpretation.
• Orthologue Sequences Across Species: Includes orthologous sequences from 37 species to enable comparative genomic and evolutionary analyses.
• Tissue Expression Patterns: Provides tissue-specific expression information for IFN-regulated genes.
• Gene Regulatory Information: Contains information on gene regulatory networks and regulatory relationships influenced by interferons.

Scientific Applications:

• Infection and Immunity Research: Identifies IFN signatures in gene expression data to investigate immune responses to pathogens.
• Developmental Biology: Examines how interferons influence gene regulation during developmental processes.
• Cancer Research: Analyzes IFN-regulated gene expression patterns to support identification of potential biomarkers and therapeutic targets.

Methodology:

Compiles and integrates high-throughput gene expression data from interferon-treated cells with annotation, ontology, orthologue sequences (37 species), tissue-specific expression, and gene regulatory information.