InterProScan (EBI)

InterProScan (EBI) scans protein sequences against the InterPro protein signature databases to predict protein domains, families, and functional annotations for large-scale genomic and proteomic analyses.

Key Features:

• Protein signature scanning: Scans protein sequences against the InterPro protein signature databases to identify domains, families, and signatures.
• Java-based architecture: Implements a Java-based architecture that supports execution across multiprocessor machines and conventional clusters.
• Scalable distributed data analysis: Performs distributed data analysis to enable scalable processing of large sequence datasets on multiprocessor and cluster environments.
• Framework reimplementation and output enhancements: Includes a reimplemented software framework and enhanced outputs for more detailed and comprehensive annotation results.
• Integration with EMBL-EBI services: Integrates with EMBL-EBI resources including EBI Search and the Job Dispatcher framework and supports access via RESTful and SOAP APIs.

Scientific Applications:

• Protein function prediction: Predicts protein function by identifying InterPro signatures, domains, and families within sequences.
• Large-scale genomic and proteomic annotation: Enables characterization and annotation of large datasets in genomic and proteomic studies, including projects involving millions of sequences.
• Biological process and disease research: Supports studies of protein roles in biological processes and diseases through domain and signature annotation.

Methodology:

Scans protein sequences against the InterPro protein signature databases using a Java-based distributed analysis framework that runs on multiprocessor machines and clusters and integrates with EMBL-EBI EBI Search and the Job Dispatcher framework via RESTful and SOAP APIs.