INTERSPIA

INTERSPIA analyzes protein-protein interaction (PPI) patterns across multiple species to identify functionally associated proteins and investigate the evolution of protein functions.

Key Features:

• Functional Association Discovery: Given a set of input proteins, identifies additional proteins that are functionally linked to the inputs.
• Multi-Species PPI Pattern Analysis: Searches for and compares PPI patterns across multiple species using a server-side pipeline to reveal evolutionary differences in interactions.

Scientific Applications:

• Comparative PPI Evolution: Analyze how protein-protein interactions change among species to infer evolutionary constraints and divergence.
• Cross-Species Functional Association: Identify conserved and species-specific functionally linked proteins starting from user-specified protein sets.
• Investigation of Protein Function Evolution: Explore the evolution of protein functions by examining multi-species PPI patterns.

Methodology:

A server-side pipeline searches for PPI patterns across multiple species and identifies proteins functionally associated with provided protein sets.