IntSIde

IntSIde integrates chemical and biological data to elucidate molecular mechanisms underlying drug side effects.

Key Features:

• Database coverage: Catalogs 1,175 side effects associated with 996 distinct drugs.
• Integrated chemical and biological features: Divides drug features into eight categories including biological aspects (drug targets and off-targets; pathways, molecular functions, and biological processes) and chemical aspects (molecular fingerprints, scaffolds, and chemical entities).
• Biological data integration: Incorporates protein interactions and disease-related genes to support mechanistic interpretation of side effects.

Scientific Applications:

• Pharmacology and toxicology research: Links chemical properties of drugs to biological effects to inform pharmacology and toxicology studies.
• Drug development: Aids anticipation of potential side effects during early-stage drug design and testing.
• Mechanistic interpretation: Facilitates elucidation of molecular mechanisms underlying adverse drug reactions through integrated datasets.

Methodology:

Integration of chemical and biological datasets, categorization of drug features into eight groups (drug targets and off-targets; pathways, molecular functions, biological processes; molecular fingerprints; scaffolds; chemical entities), and incorporation of protein interactions and disease-related genes.