IPD

IPD provides curated sequence databases of polymorphic immune-system genes to support research in immunogenetics, transplantation compatibility, and tumor immunology.

Key Features:

• Collaborative curation: Collaborates with specialist groups and nomenclature committees to produce curated and standardized sequence records.
• IPD-KIR: Contains allelic sequences of Killer-cell Immunoglobulin-like Receptors (KIR) documenting polymorphism relevant to immune regulation.
• IPD-MHC: Contains sequences of the Major Histocompatibility Complex (MHC) across various species for studies of antigen presentation and immune recognition.
• IPD-human platelet antigens: Catalogues alloantigens expressed exclusively on platelets to inform transfusion and hematological compatibility assessments.
• IPD-ESTDAB: Provides the European Searchable Tumour cell-line database of immunologically characterized melanoma cell lines for tumor immunology research.

Scientific Applications:

• Immunogenetics research: Enables analysis of immune-system gene polymorphisms and their effects on immune responses via curated allelic and locus-specific sequences.
• Transplantation and transfusion medicine: Supports compatibility assessment and antigen-matching using human platelet antigen and MHC sequence data.
• Cancer immunotherapy research: Facilitates study of melanoma cell lines and tumor immunology for development of immune-targeted cancer therapies.

Methodology:

Expert-group curation and nomenclature committee review are used to validate and standardize sequence records prior to publication.