iPiG

iPiG integrates peptide spectrum matches (PSMs) from mass spectrometry (MS) experiments into genome browser visualizations to enable correlation of MS-based proteomic data with genomic information for proteogenomics analyses.

Key Features:

• Integration of PSMs: Maps peptide spectrum matches (PSMs) from mass spectrometry (MS) experiments into genome browser visualizations such as the UCSC Genome Browser.
• Unified proteomic–genomic comparison: Enables concurrent analysis and direct comparison of proteomic identifications with genomic annotations within a single visualization framework.
• Support for proteogenomics workflows: Facilitates correlation of MS-derived peptide identifications with genomic coordinates to address differences in data formats between proteomic and genomic datasets.

Scientific Applications:

• Proteogenomics: Correlates MS-derived peptide identifications with genomic annotations to support studies of gene expression, protein function, and genetic variation.

Methodology:

Maps peptide spectrum matches (PSMs) from mass spectrometry (MS) experiments to genome browser visualization formats (e.g., UCSC Genome Browser) to integrate proteomic and genomic data.