iReceptor

iReceptor aggregates and enables querying of Adaptive Immune Receptor Repertoire (AIRR) sequencing data across distributed repositories to support comparative analysis of antibody/B-cell and T-cell receptor repertoires.

Key Features:

• Data Integration and Sharing: Links distributed AIRR-seq repositories and supports sequence-level and metadata queries across studies and institutions.
• Comparative Analysis: Enables comparison of large-scale antibody/B-cell and T-cell receptor repertoires across datasets.
• Biomedical Research Support: Integrates AIRR-seq data from diverse disease conditions to support vaccine development, autoimmune and infectious disease research, and cancer therapeutic monitoring.
• Standards and Community Alignment: Implements and supports AIRR Community protocols and standards for describing, reporting, sharing, and comparing AIRR-seq data.

Scientific Applications:

• Vaccine Development: Facilitates analysis of immune receptor repertoire changes relevant to vaccine response characterization.
• Autoimmune and Infectious Disease Research: Supports investigation of repertoire dynamics and immune mechanisms in autoimmune and infectious diseases.
• Cancer Therapeutics Monitoring: Enables characterization and comparison of immune receptor repertoires for monitoring responses to cancer immunotherapies.

Methodology:

Operates as a federated system connecting multiple AIRR-seq repositories and supporting cross-repository sequence and metadata queries while adhering to AIRR Community protocols.