SocialViruses

SocialViruses integrates quantitative phage-bacteria and phage-phage interaction networks to rationally design optimized phage cocktails that maximize host range and virulence while minimizing redundancy and antagonism.

Key Features:

• Cocktail optimization algorithms: SocialViruses selects up to twelve viruses using two alternative algorithms for optimized cocktail design.
• Quantitative interaction integration: The tool integrates quantitative host range infection matrices and virus-virus interaction matrices to guide cocktail design.
• Quality metrics reporting: SocialViruses produces a detailed report with key quality metrics for designed cocktails.
• Multiple cocktail definition: Users can define multiple cocktails while minimizing viral interference and managing co-infection redundancy.

Scientific Applications:

• Phage therapy design: SocialViruses enables rational design of phage cocktails as an alternative to antibiotics, addressing heritable bacterial resistance and cross-resistance from repeated phage exposure.
• Host range optimization: The tool optimizes cocktail selection based on host range and virulence while accounting for the complex, non-binary nature of virus-host interactions.
• Antagonism minimization: SocialViruses minimizes viral interference and antagonism between phages in designed cocktails.

Methodology:

SocialViruses integrates quantitative host range infection matrices and virus-virus interaction matrices, using two alternative algorithms to select up to twelve viruses for optimized cocktail design.