IsoGeneGUI

IsoGeneGUI identifies genes exhibiting monotonic increases or decreases in expression across varying doses to support dose-response genomic analyses.

Key Features:

• Monotonic Trend Identification: Detects genes whose expression levels change consistently (increase or decrease) with increasing dosage.
• Multiple Test Statistics: Employs multiple statistical tests to assess monotonic trends across dose levels.
• Integration with Bioconductor: Operates within the Bioconductor ecosystem to enable interoperability with R and other Bioconductor packages.

Scientific Applications:

• Dose-Response Studies: Analyzes how gene expression varies with different doses of drugs or treatments to characterize dose-dependent effects.
• Gene Function Analysis: Identifies genes with monotonic expression trends to inform functional genomics investigations.
• Therapeutic Target Identification: Highlights genes with dose-dependent expression changes as potential candidates for therapeutic targeting.

Methodology:

Operates within R and Bioconductor and applies multiple statistical tests to detect monotonic (increasing or decreasing) gene expression trends across dose levels.