iTritiKBdb

iTritiKBdb catalogs and analyzes protein–protein interactions between wheat (Triticum species) and the Karnal bunt pathogen Tilletia indica to elucidate molecular mechanisms of infection and host immune responses.

Key Features:

• Comprehensive Database: Provides functional annotations for host and pathogen proteins, including subcellular localization, protein domains, KEGG pathways, and Gene Ontology (GO) terms.
• Interactomics Tool: Predicts and represents protein–protein interaction networks between wheat and T. indica and supports enriched comparison of predicted interactions.
• Functional Annotations of Regulatory and Virulence Factors: Includes annotated transcription factors from wheat and candidate effectors from T. indica linked to interaction data.

Scientific Applications:

• Infection mechanism elucidation: Support identification of host and pathogen proteins and interactions involved in Karnal bunt infection by Tilletia indica.
• Host–pathogen interactome mapping: Enable mapping and comparative analysis of wheat–T. indica protein–protein interaction networks.
• Crop resistance and management research: Aid selection of candidate transcription factors and pathogen effectors for studies on disease resistance and management strategies.

Methodology:

Integrates bioinformatics tools to predict and analyze protein–protein interactions between wheat and Tilletia indica and constructs enriched interaction networks using existing molecular interaction knowledge.