IUPHAR-DB

IUPHAR-DB curates and integrates expert-reviewed information on human and rodent drug targets (including G protein-coupled receptors, voltage- and ligand-gated ion channels, and nuclear hormone receptors) and associated ligand chemical data to support pharmacology and drug-discovery research.

Key Features:

• Extensive Coverage: Contains 616 gene products across four superfamilies in human and rodent model organisms, including GPCRs, voltage- and ligand-gated ion channels, and nuclear hormone receptors (49 NHRs noted).
• Nuclear Hormone Receptor Data: Provides co-regulator information, DNA binding motifs, target genes, and three-dimensional structure annotations for nuclear hormone receptors.
• Ligand Curation: Curates approximately 2000 ligand molecules with chemical structures, electronic descriptors, identifiers, link-outs, and calculated molecular properties.
• Structure–Activity and Diversity Analysis: Includes data and analytic capabilities for examining ligand structure-activity relationships and the structural diversity of compounds active at each target.
• Expert Curation: Content is compiled, curated, and peer-reviewed by domain experts from the biomedical literature.

Scientific Applications:

• Standardized Nomenclature and Target Annotation: Provides a centralized reference of standardized nomenclature and detailed annotations for drug targets.
• Mechanistic Insight: Supports analysis of genetic, functional, and pathophysiological properties of receptors and ion channels.
• Drug Discovery and Ligand-Target Studies: Facilitates drug-discovery workflows through curated ligand-target interaction data, electronic descriptors, and calculated molecular properties.
• Translational Research on Disease Mechanisms: Enables study of pathophysiological mechanisms and identification of potential therapeutic strategies via integrated target and ligand data.

Methodology:

Calculated electronic descriptors and molecular properties were generated for curated ligand chemical structures, and content was compiled and peer-reviewed from the biomedical literature by expert curators.