ivTerm

ivTerm provides interactive visualization and comparison of functional analysis results from meta-omics data to facilitate exploration of functional annotations and associated genes in metagenomics and meta-transcriptomics datasets.

Key Features:

• Interactive visualization: Interactive exploration of functional terms and their corresponding genes within meta-omics datasets.
• Customizable charts: Generation of customizable chart types for representing functional annotations and gene involvement.
• Cross-experiment comparison: Comparison of functional analysis outcomes across multiple experiments to identify consistent patterns or variations.
• Automated term descriptions: Retrieval of term descriptions from database web servers to annotate functional terms.
• Meta-omics support: Explicit support for analysis of metagenomics and meta-transcriptomics datasets from environmental samples.

Scientific Applications:

• Environmental meta-omics analysis: Interpretation of functional annotations in complex environmental sequencing datasets.
• Human gut metagenomes: Exploration of functional profiles and gene-level contributions in human gut metagenome studies.
• Coral symbiome meta-transcriptomes: Analysis of functional expression and annotation in coral symbiont meta-transcriptomic datasets.
• Functional genomics integration: Integration of functional annotation and gene-level data for comparative functional genomics investigations.

Methodology:

Implements an interactive R-shiny application for dynamic manipulation and visualization of functional analysis results and retrieves term descriptions from database web servers.