J-Circos

J-Circos visualizes chromosomal interactions and fusion transcripts as interactive circular plots to support exploration of genomic rearrangements and structural variation.

Key Features:

• Interactive Circos-style visualization: Renders circular ideograms derived from Circos concepts into interactive plots for exploration of chromosomal interactions and fusion transcripts.
• Dynamic data integration: Allows addition of data to existing plots to update visualizations during analysis.
• Zoom functions: Provides zoom in/out capabilities to focus on specific genomic regions within the circular layout.
• Support for flat data formats: Accepts flat data formats as input for generating visualizations.

Scientific Applications:

• Chromosomal interaction analysis: Visualization of intra- and inter-chromosomal contacts to aid study of genome architecture and rearrangements.
• Fusion transcript characterization: Display of fusion events to support interpretation of fusion transcripts from sequencing data.
• Next-generation sequencing data interpretation: Exploration and iterative visualization of structural variants and fusion calls derived from NGS datasets.

Methodology:

Implemented in Java; interactive features including zoom are realized via graphical rendering techniques; supports flat data formats and dynamic addition of data to existing plots.