JBrowse 2

JBrowse 2 visualizes and enables analysis of genome annotations and structural variation to support genomic, comparative, and evolutionary investigations.

Key Features:

• Enhanced Visualization: Provides visualizations for structural variation including synteny, dotplots, breakpoints, and gene fusions to explore genomic rearrangements and evolutionary patterns.
• Whole-Genome Overviews: Offers comprehensive views of entire genomes to assess genomic architecture and variation.
• Multi-Genome Navigation: Opens and navigates multiple genomes simultaneously to enable comparative genomics and cross-species analyses.
• Session Sharing: Supports sharing of analysis sessions to enable collaborative examination of genomic data.
• Modern Web Technology: Implemented via a ground-up redesign using contemporary web technologies to improve performance.

Scientific Applications:

• Structural Genomics: Visualizes and analyzes structural variations, breakpoints, and gene fusions within genomes.
• Comparative Genomics: Enables cross-species comparisons and synteny analyses using multi-genome and whole-genome views.
• Evolutionary Biology: Supports investigation of evolutionary relationships and genome evolution through visualization of conserved and rearranged regions.
• Synteny and Rearrangement Analysis: Uses synteny views and dotplots to identify chromosomal rearrangements and conserved genomic regions.

Methodology:

Implemented via a ground-up redesign using modern web technologies to improve performance, with implementation notes provided for deployment and customization.