jhubiobank

jhubiobank provides a curated repository of annotated nerve sheath tumor biospecimens, patient-derived cell lines, and xenografts with linked genomic and transcriptomic datasets to support research on neurofibromatosis type 1 (NF1) tumors.

Key Features:

• Annotated Biospecimens: The repository contains 55 nerve sheath tumor samples from 23 individuals with comprehensive clinical annotations and primary tumor specimens.
• Patient-derived Cell Lines and Xenografts: Includes patient-derived cell lines and xenografts established from NF1-associated nerve sheath tumors for experimental and preclinical studies.
• Genomic and Transcriptomic Characterization: High-throughput genomic and transcriptomic sequencing and analyses have been performed on the collected specimens.

Scientific Applications:

• Biological Studies: Enables investigation of tumor heterogeneity, mechanisms, and progression in NF1-associated nerve sheath tumors using annotated specimens and molecular data.
• Preclinical Therapeutic Development: Supports testing of candidate therapeutics in preclinical models using patient-derived cell lines and xenografts.
• Genomic Research: Facilitates identification of mutations and genetic alterations in NF1-related tumors through integrated genomic and transcriptomic datasets.

Methodology:

Specimens underwent collection and clinical annotation, and high-throughput genomic and transcriptomic sequencing techniques were employed to generate the molecular profiles.