KA-Search

KA-Search performs exhaustive searches of antibody variable domain sequences to identify sequence-similar antibodies for analyses of immunogenicity and antigen specificity.

Key Features:

• Rapid and Exhaustive Search: Performs rapid, exhaustive searches across billions of antibody variable domains to identify sequences with similar amino acid composition, including within complementarity-determining regions (CDRs).
• Optimized for Antibody Specificity: Tailored for antibody sequence analysis and allows focus on any user-defined region of an antibody, including variable domains and CDRs.
• High-Throughput Performance: Enables searches across the 2.4 billion antibody sequences in the OAS database, returning the most similar sequences within 30 minutes or producing a representative subset of 10 million sequences in less than 9 seconds.

Scientific Applications:

• Immunogenicity Assessment: Identify naturally occurring, sequence-similar antibodies from healthy or diseased repertoires to inform immunogenicity analyses.
• Antigen Specificity and Therapeutic Development: Retrieve sequence-similar antibodies to support inference of antigen specificity and selection of candidates for therapeutic antibody development and disease research.

Methodology:

Searches for sequence identity across specified antibody regions, allowing user-defined regions of interest such as variable domains or specific CDRs.