KEGGCharter

KEGGCharter visualizes genomic potential and transcriptomic expression by mapping omics data onto KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways to support interpretation of metabolic and functional profiles.

Key Features:

• Pathway Visualization: Maps differential gene expression and genomic potential onto KEGG metabolic pathways for contextualized visualization of metabolic functions.
• Taxonomic Assignment: Displays taxonomic assignment of enzymes within pathways to attribute functional contributions to specific taxa in metagenomic contexts.
• Integration with Other Tools: Integrates functional annotation and characterization results from UPIMAPI and reCOGnizer to combine annotations with pathway mapping.
• Large-scale Omics Data Handling: Supports analysis of large datasets typical of metagenomics, metatranscriptomics, and metaproteomics experiments.

Scientific Applications:

• Microbial Ecology: Enables exploration of functional potential and species-level contributions within microbial communities by mapping gene content and expression onto KEGG pathways.
• Biotechnology: Assists metabolic engineering and industrial microbiology by visualizing pathway-level effects of gene expression and genomic potential.
• Systems Biology: Supports interpretation of pathway-scale gene expression changes for studying system responses to environmental or genetic perturbations.

Methodology:

Maps differential gene expression and genomic potential onto KEGG pathways, displays taxonomic assignment of pathway enzymes, and integrates functional annotations and outputs from UPIMAPI and reCOGnizer for analysis of metagenomics, metatranscriptomics, and metaproteomics datasets.