Keyboard

Keyboard implements dose-finding designs in R for oncology trials to identify the maximum tolerated dose (MTD) and optimal biological dose (OBD) for cytotoxic and cytostatic agents.

Key Features:

• Design implementation: Implements the Keyboard single-agent MTD design (Yan et al.), drug-combination MTD designs (Pan et al.), and the phase I/II OBD-finding method (Li et al.).
• Dose escalation and de-escalation boundaries: Functions beginning with get.boundary(...) determine dose escalation and de-escalation boundaries.
• MTD selection: Functions beginning with select.mtd(...) identify the MTD at trial completion.
• OBD selection: Functions beginning with select.obd(...) select the OBD at trial completion.
• Operating characteristics: Functions beginning with get.oc(...) generate operating characteristics for design evaluation.
• Bayesian designs: Integrates Bayesian statistical designs for dose-finding analyses.

Scientific Applications:

• Single-Agent Trials: Facilitates MTD determination for single-agent oncology trials targeting prespecified toxicity rates.
• Drug-Combination Trials: Supports MTD finding in combination trials involving multiple agents.
• Phase I/II Trials: Enables simultaneous consideration of toxicity and efficacy to determine OBD in phase I/II trials, including for cytostatic agents.

Methodology:

Implements the Keyboard design (Yan et al.), combination MTD designs (Pan et al.), and the phase I/II OBD method (Li et al.); provides functions get.boundary(...), select.mtd(...), select.obd(...), and get.oc(...); and integrates Bayesian statistical designs.