KinCytE

KinCytE links kinase inhibitors to cytokine and chemokine release and signaling pathways to identify and rank kinase regulators and FDA-approved kinase inhibitors that modulate cytokine and chemokine activity.

Key Features:

• Kinase–cytokine linking: Bridges kinase inhibitors with cytokine and chemokine release and signaling pathways.
• Protein kinase exploration: Enables exploration of the role of protein kinases in regulating specific cytokines and chemokines.
• Ranked inhibitor lists: Generates ranked lists of FDA-approved kinase inhibitors that influence cytokine or chemokine activity.
• Cytokine signaling network visualization: Produces visualizations of cytokine signaling networks to reveal regulatory relationships.
• Molecular regulator identification: Identifies molecular regulators and potential therapeutic opportunities within kinase–cytokine interactions.

Scientific Applications:

• Regulation of immune processes: Study regulation of inflammation, immune response, and cell differentiation mediated by cytokines and chemokines.
• Disease mechanism analysis: Investigate kinase-mediated cytokine and chemokine dysregulation in diseases including cancer.
• Drug repurposing and prioritization: Prioritize FDA-approved kinase inhibitors for modulation of cytokine or chemokine activity as potential therapeutic strategies.
• Signaling network mapping: Elucidate cytokine signaling networks and kinase regulatory relationships to inform target selection.

Methodology:

Computationally links kinase inhibitors to cytokine and chemokine release and signaling pathways, generates ranked lists of FDA-approved kinase inhibitors that influence cytokine or chemokine activity, and produces visualizations of cytokine signaling networks.