KinMap

KinMap integrates and visualizes human kinome data to enable analysis of compound profiling, structural features, and disease associations linked to kinase inhibitors.

Key Features:

• Dataset integration: Integrates kinase-related datasets from ChEMBL, the Protein Data Bank, and the Center for Therapeutic Target Validation platform.
• Kinome tree mapping: Links biochemical, structural, and disease-association data directly to the human kinome tree.
• Compound profiling visualization: Visualizes compound profiling and functional relationships across the kinase class.
• Structural feature visualization: Displays structural features of kinases in the context of the kinome tree.
• Therapeutic association queries: Supports complex queries concerning kinase disease involvement and potential therapeutic uses of kinase inhibitors.
• Annotated image generation: Produces annotated images of the kinome tree for visual representation of mapped data.
• Naming unification: Recognizes alternative kinase names and links them to a unified naming scheme.
• Input/output flexibility: Accommodates multiple input and output formats for data exchange.

Scientific Applications:

• Drug discovery and repurposing: Identify new therapeutic indications for existing kinase inhibitors and prioritize kinases for drug development.
• Integrative kinase-disease analysis: Correlate biochemical, structural, and disease-association data to investigate kinase involvement in disease.
• Structure-function studies: Examine structural features and functional relationships within the kinase family in a kinome-wide context.
• Compound profiling interpretation: Map compound activity data onto the kinome tree to interpret selectivity and off-target profiles.

Methodology:

Integrates datasets from ChEMBL, the Protein Data Bank, and the Center for Therapeutic Target Validation platform; maps integrated biochemical, structural, and disease-association data onto the human kinome tree; recognizes and unifies alternative kinase names; generates annotated kinome tree images and supports multiple input/output formats.