Kleborate

Kleborate provides genomic surveillance and analysis of Klebsiella pneumoniae and the Klebsiella pneumoniae species complex (KpSC), reporting antimicrobial resistance (AMR)–related genotypes and enabling detection and typing from gut metagenomes.

Key Features:

• Genomic surveillance framework: Provides a structured approach for monitoring and interpreting Klebsiella pneumoniae genome data to assess global population structure and AMR trends.
• Analysis of clinically important genomic features: Consolidates interrogation of clinically important genomic features to support epidemiological analyses and clinical interpretation.
• Application to public genomes: Has been applied to publicly available Klebsiella genomes, including clinical isolates from a pan-European study of carbapenemase-producing Klebsiella, to identify AMR and population trends.
• Detection and typing from metagenomes: Detects and types Klebsiella pneumoniae directly from gut metagenomes.

Scientific Applications:

• Epidemiological research: Enables investigation of global population structure and AMR trends in Klebsiella pneumoniae.
• Clinical diagnostics: Supports identification and typing of Klebsiella pneumoniae strains from clinical samples to inform diagnostic and treatment considerations.
• Public health surveillance: Facilitates monitoring and control of the spread of antimicrobial-resistant Klebsiella in public health contexts.

Methodology:

Analyzes Klebsiella genomes and performs detection and typing directly from gut metagenomic data.