KO2Pathway

KO2Pathway maps KEGG Orthology (KO) identifiers to KEGG pathways and generates summaries of pathway descriptions with associated KO counts.

Key Features:

• KEGG Pathway Mapping: Retrieves pathway information from KEGG and generates a summary of pathway descriptions with the associated KO counts.
• Custom Pathway Exclusion: Allows for excluding specific pathways based on custom-defined terms.
• Caching: Supports caching of KO-to-pathway mappings to avoid repetitive queries to the KEGG API.

Scientific Applications:

• Functional Annotation: Maps KO identifiers to KEGG pathways for functional interpretation of genomic or metagenomic data.
• Pathway Analysis: Generates summaries of pathway descriptions with KO counts for downstream biological interpretation.

Methodology:

KO2Pathway queries the KEGG API to retrieve pathway information for KO identifiers, with optional caching of KO-to-pathway mappings and filtering of pathways based on custom-defined exclusion terms.