LacOp

LacOp simulates the lac operon to model prokaryotic gene regulation and to explore how genotype changes affect lactose metabolism in Escherichia coli.


Key Features:

  • Simulation of the lac operon: Models lac operon function in Escherichia coli to represent transcriptional regulation.
  • Genotype manipulation: Allows exploration and manipulation of different genotypes to observe effects on regulation.
  • Modeling of metabolism and regulation: Represents lactose metabolism and gene regulation mechanisms associated with the lac operon.

Scientific Applications:

  • Genetics education: Supplements high school and undergraduate instruction on prokaryotic gene regulation by providing simulation-based exploration of the lac operon.
  • Conceptual investigation: Enables examination of relationships between genotype variation and regulatory outcomes in Escherichia coli.

Methodology:

Computational simulation of the lac operon's function in Escherichia coli with the capability to explore and manipulate different genotypes.

Topics

Details

Cost:
Free of charge
Tool Type:
web application
Operating Systems:
Mac, Linux, Windows
Added:
9/7/2022
Last Updated:
11/24/2024

Operations

Publications

Charczenko R, McMahon M, Kandl K, Rutherford R. <scp>LacOp</scp>: A free web‐based lac operon simulation that enhances student learning of gene regulation concepts. Biochemistry and Molecular Biology Education. 2022;50(4):360-368. doi:10.1002/bmb.21638. PMID:35723033.