LacOp
LacOp simulates the lac operon to model prokaryotic gene regulation and to explore how genotype changes affect lactose metabolism in Escherichia coli.
Key Features:
- Simulation of the lac operon: Models lac operon function in Escherichia coli to represent transcriptional regulation.
- Genotype manipulation: Allows exploration and manipulation of different genotypes to observe effects on regulation.
- Modeling of metabolism and regulation: Represents lactose metabolism and gene regulation mechanisms associated with the lac operon.
Scientific Applications:
- Genetics education: Supplements high school and undergraduate instruction on prokaryotic gene regulation by providing simulation-based exploration of the lac operon.
- Conceptual investigation: Enables examination of relationships between genotype variation and regulatory outcomes in Escherichia coli.
Methodology:
Computational simulation of the lac operon's function in Escherichia coli with the capability to explore and manipulate different genotypes.
Topics
Details
- Cost:
- Free of charge
- Tool Type:
- web application
- Operating Systems:
- Mac, Linux, Windows
- Added:
- 9/7/2022
- Last Updated:
- 11/24/2024
Operations
Publications
Charczenko R, McMahon M, Kandl K, Rutherford R. <scp>LacOp</scp>: A free web‐based lac operon simulation that enhances student learning of gene regulation concepts. Biochemistry and Molecular Biology Education. 2022;50(4):360-368. doi:10.1002/bmb.21638. PMID:35723033.
DOI: 10.1002/bmb.21638
PMID: 35723033