Laminin database

Laminin database provides a curated and cross‑referenced resource aggregating protein, gene structure, gene expression, tissue distribution, therapy, and nomenclature information for laminin family proteins and associated molecules to support studies of their biological roles across species.

Key Features:

• Coverage: Detailed entries for laminins, receptors, extracellular binding proteins, and other related proteins.
• Data types: Protein information, gene structure, gene expression, tissue distribution, and therapy-related data are provided for each entry.
• Species support: Data include Homo sapiens, Mus musculus, and Rattus norvegicus.
• Data integration: Combines automatically retrieved information with manually curated annotations to produce annotated datasets.
• PubMed linkage: Direct links to PubMed articles covering biological functions, knockout animal models, genetic diseases, immune responses, and associations with lymphomas and leukemias.
• Nomenclature resource: Contains a dedicated laminin nomenclature resource to standardize identification.

Scientific Applications:

• Functional characterization: Exploration of laminin biological functions, including tissue distribution and therapy relevance.
• Genetic and animal model studies: Analysis of knockout animal models and genetic disease associations linked to specific molecules.
• Immunology and oncology research: Investigation of immune responses and associations with lymphomas and leukemias.
• Hemopoietic system studies: Provision of data relevant to research on the hemopoietic system.

Methodology:

Integrates automatically retrieved data with manually curated annotations and provides direct links to PubMed literature.