LAMP

LAMP provides a curated database of natural and synthetic antimicrobial peptides (AMPs) with antimicrobial activity and cytotoxicity annotations to support AMP discovery and design.

Key Features:

• Content: Contains 5,547 AMP entries, including 3,904 natural AMPs and 1,643 synthetic peptides, with antimicrobial activity and cytotoxicity data.
• Query Functionality: Supports searches using simple keywords and complex combinatorial conditions for flexible retrieval of AMPs.
• Cross-linking and Similarity Functions: Enables exploration of relationships between peptides and identification of top similar AMPs based on peptide properties.

Scientific Applications:

• AMP discovery: Facilitates identification of candidate antimicrobial peptides by aggregating sequence, activity, and cytotoxicity information.
• Rational AMP design: Supports design and optimization of new peptides through similarity-based comparison and relationship exploration.
• Candidate prioritization: Aids selection of peptides with favorable antimicrobial efficacy and reduced cytotoxicity for further experimental evaluation.

Methodology:

Implements keyword and combinatorial-condition searches plus cross-linking and similarity functions to identify top similar AMPs and integrates entries annotated with antimicrobial activity and cytotoxicity.