Lead-OR

Lead-OR integrates preoperative neuroimaging, stereotactic planning, high-resolution atlas data, and intraoperative electrophysiological recordings to align anatomical targets with physiological signals for electrode placement in deep brain stimulation (DBS) surgery.

Key Features:

• Multimodal data integration: Combines MRI, stereotactic planning data, high-resolution atlas data, microelectrode recordings (MERs), and local field potential (LFP) recordings to provide combined anatomical and physiological information.
• Real-time visualization of trajectories: Fuses stereotactic planning, atlas data, and electrophysiological recordings to visualize DBS electrode implant trajectories during intraoperative assessment.
• Retrospective validation: Assessed on a retrospective cohort of 52 DBS patients to evaluate alignment between neuroimaging features and electrophysiological recordings.
• Translational impact: Provides multimodal alignment and visualization intended to improve accuracy of electrode localization and inform clinical decision-making in DBS procedures.

Scientific Applications:

• Intraoperative electrode placement: Aligns anatomical and physiological data to support positioning of DBS electrodes during surgery.
• Structure–function research: Enables research into correlations between anatomical structures (from MRI and atlases) and electrophysiological patterns (MERs, LFPs).
• Method validation studies: Supports retrospective analyses and validation of imaging-to-physiology alignment using patient cohorts.

Methodology:

Fusion of stereotactic planning data, MRI, high-resolution atlas data, and electrophysiological recordings (microelectrode recordings and local field potentials) with advanced visualization techniques to enable real-time assessment and adjustment of DBS electrode trajectories.