LeukmiR

LeukmiR catalogs microRNAs (miRNAs) and their target genes associated with acute lymphoblastic leukemia (ALL) in human and mouse by integrating in silico predicted and experimentally validated miRNAs with genomic target annotations to support analysis of miRNA:mRNA interactions and signaling pathways.

Key Features:

• Comprehensive Data Integration: Includes miRNAs associated with ALL with sequences, descriptions, and mapped target genes for both human and mouse.
• Predicted and Validated miRNAs: Integrates in silico predicted miRNAs alongside experimentally validated miRNAs linked to ALL.
• Genomic Target Annotations: Provides genomic locations of targets including 3'UTRs, 5'UTRs, and exons.
• Querying by Identifiers: Supports queries by miRNA ID, accession number, sequence, target genes, Ensemble-ID, and Entrez-ID for human and mouse data.
• miRNA:mRNA Interaction Networks: Assembles miRNA:mRNA interaction networks mapped onto signaling pathways.
• Novel microRNAs: Reports 51 novel microRNAs not previously described in the context of ALL.
• Ontology Annotations: Provides gene ontology and disease ontology information for annotated genes.

Scientific Applications:

• Biomarker and therapeutic target discovery: Enables identification of miRNAs and target genes with potential diagnostic or therapeutic relevance in ALL.
• Pathogenesis and pathway analysis: Facilitates analysis of miRNA:mRNA interactions within signaling pathways implicated in ALL pathogenesis.
• Comparative human-mouse studies: Supports cross-species comparison of miRNA regulation between human and mouse models of ALL.
• Functional and disease annotation: Aids functional interpretation of targets using gene ontology and disease ontology data.

Methodology:

Integration of in silico predicted and experimentally validated miRNAs; mapping of target genes to genomic locations (3'UTRs, 5'UTRs, exons); assembly of miRNA:mRNA interaction networks within signaling pathways; indexing for queries by miRNA ID, accession number, sequence, target gene, Ensemble-ID, and Entrez-ID for human and mouse.