LincSNP

LincSNP maps disease-associated single nucleotide polymorphisms (SNPs) and linked variants onto human large intergenic non-coding RNAs (lincRNAs) and annotates these associations to support investigation of how non-coding variants influence disease susceptibility.

Key Features:

• Extensive SNP repository: Contains approximately 140,000 disease-associated SNPs and SNPs in linkage disequilibrium mapped to approximately 5,000 human lincRNAs.
• GWAS integration: Integrates genome-wide association study (GWAS) data to identify disease-associated SNPs.
• Genomic mapping: Maps SNPs to lincRNAs by genomic location.
• Comprehensive functional annotations: Provides detailed functional annotations for each SNP–lincRNA association.
• Experimentally supported associations: Includes experimentally validated SNP–lincRNA–disease associations.

Scientific Applications:

• lincRNA–disease association studies: Supports investigation of lincRNA involvement in human diseases by linking non-coding variants to lincRNAs.
• Mechanism elucidation: Facilitates elucidation of molecular mechanisms by which non-coding SNPs affect lincRNA function and disease susceptibility.
• GWAS interpretation: Aids interpretation of GWAS signals in non-coding genomic regions and prioritization of candidate variants for experimental follow-up.

Methodology:

Integrated GWAS-identified SNPs, mapped SNPs to lincRNAs by genomic location, and annotated associations with functional information derived from experimental studies.