LipidXplorer

LipidXplorer performs interpretation and quantitative characterization of complex lipidomes from shotgun mass spectrometry datasets.

Key Features:

• Versatility in Mass Spectrometers: Processes spectra acquired from any type of tandem mass spectrometer.
• Comprehensive Lipid Identification and Quantification: Identifies and quantifies molecular species across all ionizable lipid classes by considering known or assumed molecular fragmentation pathways, independent of reference mass spectra resources.
• Support for Diverse Profiling Routines: Supports high-throughput top-down screening and targeted absolute quantification of low-abundant lipid species in shotgun profiling workflows.

Scientific Applications:

• Molecular Diagnostics: Enables lipid-based molecular diagnostics by providing lipid species identification and quantification from shotgun MS data.
• Biomarker Discovery: Facilitates discovery of lipid biomarkers through comprehensive profiling of lipidomes.
• Quantitative Lipidomics: Supports detailed quantitative analysis of lipid species, including low-abundance analytes.

Methodology:

Processes shotgun mass spectrometry datasets from tandem mass spectrometers and applies rule-based identification using known or assumed molecular fragmentation pathways to identify and quantify molecular species across ionizable lipid classes, including routines for high-throughput screening and targeted absolute quantification.