LiquidAssociation

LiquidAssociation estimates and tests liquid association in gene triplets to detect higher-order interactions among genes beyond pairwise correlations.

Key Features:

• Direct and Model-Based Estimators: Provides functions to calculate both direct and model-based estimators for liquid association to quantify three-way gene interactions.
• Testing Liquid Association: Implements statistical tests for the presence of liquid association within gene triplet data.

Scientific Applications:

• Genomic Research: Enables analysis of complex multi-gene interactions in genomic studies.
• Bioconductor Integration: Integrates with the Bioconductor ecosystem to interoperate with other packages and facilitate community-driven methodological development.

Methodology:

Implemented in R and distributed via Bioconductor, with computational methods including calculation of direct and model-based estimators and statistical testing for liquid association.