Lnc2Cancer

Lnc2Cancer curates a manually reviewed database of experimentally supported associations between long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and human cancers to support molecular and clinical cancer research.

Key Features:

• Expanded database entries: Lnc2Cancer 3.0 contains 9,254 lncRNA–cancer associations covering 2,659 lncRNAs across 216 cancer subtypes and 1,049 circRNA–cancer associations covering 743 circRNAs across 70 cancer subtypes.
• Regulatory mechanisms: Experimentally supported interactions annotated include microRNAs, transcription factors (TFs), genetic variants, DNA methylation patterns, and enhancers.
• Biological functions: Annotations include effects on cell growth, apoptosis, autophagy, epithelial–mesenchymal transformation (EMT), immunity, and coding ability.
• Clinical relevance: Associations include metastasis, recurrence, circulation, drug resistance, and prognosis.
• RNA-seq Web Tool: Analysis of lncRNA expression using high-throughput RNA sequencing data.
• scRNA-seq Web Tool: Analysis of lncRNAs at single-cell resolution to assess cellular heterogeneity and specific cancer cell populations.

Scientific Applications:

• Mechanistic studies: Elucidation of molecular roles of lncRNAs and circRNAs in cancer biology.
• Translational research: Support for development of novel therapeutic strategies targeting lncRNAs and circRNAs.
• Clinical biomarker and prognosis studies: Investigation of associations with metastasis, recurrence, circulation, drug resistance, and prognosis.
• Single-cell heterogeneity analyses: Characterization of cancer cell populations via single-cell lncRNA expression profiling.

Methodology:

Manual literature curation of experimentally supported lncRNA/circRNA–cancer associations and provision of RNA-seq and single-cell RNA-seq analysis modules for expression profiling from high-throughput and single-cell RNA sequencing data.