LncACTdb

LncACTdb provides a curated repository of experimentally validated competing endogenous RNA (ceRNA) interactions and associated expression and clinical data to support analysis of ceRNA networks and precision medicine.

Key Features:

• Extensive ceRNA Interaction Data: Includes 5,669 experimentally validated ceRNA interactions across 25 species and associated with 537 diseases or phenotypes.
• Personalized ceRNA Networks: Hosts patient-specific ceRNA networks derived from data on 16,228 patients across 62 datasets from TCGA and GEO.
• Sub-cellular Localization: Curates sub-cellular and extracellular vesicle localizations of ceRNAs.
• lncRNA Biomarkers for Cancer: Contains over 10,000 experimentally supported long noncoding RNA (lncRNA) biomarkers associated with tumor diagnosis and therapy.
• Expression and Clinical Data Integration: Integrates lncRNA, mRNA, and miRNA expression profiles with clinical and pathological information from thousands of cancer patients.
• Patient-specific Network Analysis Tools: Provides analytical tools for constructing and analyzing lncRNA-related, patient-specific, and custom-designed ceRNA networks.

Scientific Applications:

• Mechanistic study of ceRNA interactions: Enables investigation of ceRNA regulatory mechanisms in complex diseases, particularly cancer.
• Biomarker discovery and validation: Supports identification and validation of lncRNA biomarkers for tumor diagnosis and therapy.
• Precision medicine and therapeutic assessment: Facilitates development and assessment of patient-specific therapeutic strategies using individualized ceRNA networks.

Methodology:

Manual curation of experimentally validated interactions from peer‑reviewed literature and reputable data sources, and integration of expression and clinical datasets from TCGA and GEO.