LncCE

LncCE provides a detailed expression atlas of cellularly-elevated long non-coding RNAs (lncRNAs) in human single cells across normal and cancer tissues by analyzing 181 single-cell RNA sequencing datasets.

Key Features:

• CE lncRNA entries: The resource encompasses 87,946 entries of cellularly-elevated lncRNAs across 149 cell types.
• Search functionality: Two main search options are provided via a given lncRNA name or cell type.
• Expression analysis: Results emphasize both qualitative and quantitative expression features of lncRNAs across different cell types.
• Co-expression analysis: The resource provides co-expression data of lncRNAs with protein-coding genes.
• Functional involvement: The resource includes information on lncRNA involvement in biological functions.
• Cancer expression changes: Quantitative visualizations of lncRNA expression changes in cancers compared to control samples are provided.
• Clinical associations: Clinical associations with patients' overall survival are included.

Scientific Applications:

• lncRNA expression profiling: Systematic exploration of cellularly-elevated lncRNAs across normal and cancer tissues at single-cell resolution.
• Cancer research: Investigation of lncRNA expression changes in cancers compared to control samples and their clinical associations with patient overall survival.
• Functional genomics: Analysis of lncRNA co-expression with protein-coding genes and their involvement in biological functions.

Methodology:

The resource was constructed by analyzing 181 single-cell RNA sequencing datasets involving 20 fetal normal tissues, 59 adult normal tissues, 32 adult cancer types, and 5 pediatric cancer types.