LncExpDB

LncExpDB provides a curated expression database of human long non-coding RNAs (lncRNAs), aggregating expression profiles and predicted lncRNA–mRNA interactions to support analysis of lncRNA functions across diverse biological conditions.

Key Features:

• Comprehensive expression profiles: Contains expression data for 101,293 high-quality human lncRNA genes derived from 1,977 samples across 337 distinct biological conditions organized into nine biological contexts.
• Expression reliability and capacity estimation: Evaluates transcriptional reliability and estimates functional capacities of lncRNAs based on their expression characteristics.
• Featured gene identification: Identifies 25,191 featured lncRNA genes selected for likely functional relevance according to expression patterns and interactions.
• LncRNA–mRNA interaction network: Provides a repository of 28,443,865 predicted interactions between lncRNAs and protein-coding mRNAs indicating potential regulatory partnerships.

Scientific Applications:

• Functional characterization: Enables functional studies of human lncRNAs by supplying comprehensive expression profiles across conditions.
• Regulatory network analysis: Supports exploration of lncRNA regulatory roles through the provided lncRNA–mRNA interaction predictions and expression data.
• Experimental prioritization: Assists experimental design by predicting functional lncRNAs and their interacting partners for targeted follow-up.

Methodology:

Data compilation involved integration and curation of expression data from multiple sources to produce the presented expression profiles and interaction repository.