LNCipedia

LNCipedia provides a curated database of human long non-coding RNA (lncRNA) transcripts with annotations of protein-coding potential, proteomics evidence, and cross-species conservation for lncRNA research.

Key Features:

• Extensive Database: LNCipedia 3.0 incorporates over 90,000 newly annotated lncRNA transcripts.
• Coding-potential Annotation: The database evaluates protein-coding potential and flags high-confidence non-coding transcripts.
• Proteomics Reprocessing: Large-scale proteomics data are reprocessed to provide evidence for or against peptide translation of lncRNAs.
• Conservation Analysis: Implements conservation assessment of lncRNA genes across species including human, mouse, and zebrafish.

Scientific Applications:

• Novel lncRNA Discovery: Identify and catalogue novel lncRNA genes and transcript isoforms.
• Evolutionary Analysis: Analyze evolutionary conservation of lncRNAs across human, mouse, and zebrafish to infer functional relevance.
• Functional Genomics: Investigate potential regulatory roles and translational potential of lncRNAs using coding-potential and proteomics evidence.

Methodology:

Annotation and curation include evaluation of protein-coding potential, reprocessing of large-scale proteomics data, conservation assessment across human, mouse, and zebrafish, and integration of publicly available genomic datasets.