lncR2metasta

lncR2metasta catalogs 1,238 experimentally supported associations between 304 long non-coding RNAs (lncRNAs) and 39 cancer metastatic events (CMEs) across 54 human cancer subtypes to support research into lncRNA-mediated mechanisms of metastasis.

Key Features:

• Curated associations: Documents 1,238 experimentally supported lncRNA–CME associations linking 304 distinct lncRNAs to 39 CMEs across 54 human cancer subtypes.
• CME taxonomy: Includes specific metastatic events and stages such as invasion, intravasation, extravasation, and proliferation.
• LncRNA identifiers: Provides lncRNA symbol, category, Entrez ID, and Ensembl ID for precise molecular identification.
• Genomic context: Records genomic location and strand information for each lncRNA entry.
• Association description: Summarizes the specific relationship between each lncRNA and the associated CME.
• Experimental details: Captures the type of experiment and detection methods used to establish each association.
• Expression pattern: Reports how lncRNA expression changes in relation to the CME.
• Targets and pathways: Lists reported target genes or pathways influenced by each lncRNA.
• Regulatory role: Specifies the functional impact of the lncRNA on the metastatic event.
• Cancer type annotation: Indicates the specific human cancer subtype associated with each entry.
• Literature references: Includes citations to the original studies supporting each experimentally validated association.

Scientific Applications:

• Mechanistic investigation: Enables study of lncRNA roles in specific metastatic stages such as invasion, intravasation, extravasation, and proliferation.
• Biomarker discovery: Supports identification of lncRNAs as potential biomarkers for early metastasis detection.
• Target and pathway analysis: Facilitates identification of lncRNA-associated target genes and signaling pathways implicated in metastasis.
• Cross-subtype comparison: Allows comparative analyses of lncRNA–CME associations across 54 human cancer subtypes to detect subtype-specific patterns.
• Therapeutic prioritization: Informs prioritization of lncRNAs for experimental validation and development of treatment strategies targeting metastasis.

Methodology:

Entries were manually curated from published literature reporting experimentally supported associations between lncRNAs and cancer metastatic events.