lncRNAdb

lncRNAdb compiles comprehensive, referenced information on long noncoding RNAs (lncRNAs) and regulatory messenger RNAs (mRNAs) associated with biological functions in eukaryotes.

Key Features:

• Extensive Data Compilation: Compiles lncRNAs with demonstrated biological functions or associations in eukaryotic systems and includes mRNAs with regulatory roles.
• Comprehensive Entry Information: Entries include referenced RNA sequences, structural details, genomic context, expression profiles, subcellular localization, conservation status, and functional evidence.
• Search Functionality: Allows queries by published RNA names and aliases, specific sequences, species, associated protein-coding genes, tissue expression terms, and disease annotations.
• Integration with Other Databases: Links to the UCSC Genome Browser and the Noncoding RNA Expression Database (NRED) for genomic visualization and expanded expression data.
• Literature Collation: Aggregates and references literature on lncRNA functions and associations to maintain and update database entries.

Scientific Applications:

• Functional Genomics Research: Supports exploration of lncRNA roles in gene regulation, chromatin organization, and other cellular processes using sequence and functional annotations.
• Disease Association Studies: Enables investigation of lncRNA associations with diseases through curated disease-related annotations.
• Comparative Genomics: Facilitates analyses of conservation across species to assess evolutionary conservation and infer functional importance of lncRNAs.

Methodology:

Compiles information from the primary literature describing expression profiles, molecular features, and functions of individual lncRNAs and updates entries with referenced data.