lncRNAlyzr

lncRNAlyzr performs enrichment analysis for lncRNA sets to identify functional modules and visualize subnetworks connecting lncRNAs to enrichment terms.

Key Features:

• lncRNA set library database: The tool contains 33 lncRNA set libraries created by computing correlations between lncRNAs and annotated coding gene sets.
• Subnetwork visualization: Enrichment analysis results are visualized as ball-and-stick subnetworks where nodes are lncRNAs connected to enrichment terms from across selected lncRNA set libraries.
• Multi-library analysis: Users can select from multiple lncRNA set libraries for enrichment analysis.

Scientific Applications:

• Functional module identification: lncRNAlyzr identifies functional modules for sets of lncRNAs to further understanding of lncRNA biology.
• lncRNA knockdown analysis: The tool can analyze effects of lncRNA perturbation, as demonstrated by knockdown of the lncRNA CYTOR in K562 cells.

Methodology:

lncRNAlyzr computes correlations between lncRNAs and annotated coding gene sets to create lncRNA set libraries, then performs enrichment analysis on user-submitted lncRNA sets against these libraries.