lncRNASNP

lncRNASNP catalogs single nucleotide polymorphisms (SNPs) and somatic mutations in long non-coding RNAs (lncRNAs) and annotates their potential impacts on lncRNA structure, miRNA–lncRNA interactions, expression, disease associations, and drug-target relationships.

Key Features:

• Expanded Species Coverage: Includes eight eukaryotic species: human, chimpanzee, pig, mouse, rat, chicken, zebrafish, and fruitfly.
• Comprehensive Variant Data: Contains 67,513,785 variants in total and 2,387,685 human mutations, including 1,031,639 TCGA mutations and 1,356,046 CosmicNCVs.
• Functional Impact Analysis: Analyzes SNP effects on lncRNA structure and function, including detailed assessment of impacts on miRNA–lncRNA interactions.
• Expression Profiles and Disease Associations: Provides lncRNA expression profiles for six species and annotates disease- and GWAS-associated lncRNAs and variants.
• Experimental and Predicted Data Integration: Integrates experimental data and predicted associations between lncRNAs and drug targets.
• Expression Quantitative Trait Loci (eQTL) Analysis: Includes SNP effects on lncRNA expression across various tumor and normal tissues (eQTL annotation).

Scientific Applications:

• Genomic Research: Enables comparative studies of evolutionary conservation and divergence of lncRNA functions across species.
• Disease Mechanism Elucidation: Supports identification of genetic variants associated with diseases to study disease pathogenesis.
• Drug Discovery: Links SNP-induced changes in lncRNA function and interactions to potential drug targets.
• Personalized Medicine: Facilitates analysis of patient-specific mutations for development of personalized therapeutic strategies.

Methodology:

Aggregates variant datasets and annotations, performs analyses of SNP impacts on lncRNA structure and miRNA–lncRNA interactions, integrates experimental and predicted lncRNA–drug associations, and annotates eQTLs across tumor and normal tissues.