LncRNAWiki 2.0

LncRNAWiki 2.0 provides a structured, curated knowledgebase of experimentally validated human long non-coding RNAs (lncRNAs) and their associations for integrative analysis.

Key Features:

• Enhanced Database System: Implements a MySQL-backed Java architecture replacing MediaWiki to enable structured organization and efficient data curation and retrieval.
• Improved Curation Model: Supports curator submission and editing of annotations and a broader range of annotation items for precise annotation management.
• Comprehensive Data Integration: Integrates 2,512 lncRNAs and 106,242 associations across disease, function, drug interactions, molecular signatures, experimental samples, and CRISPR design.
• Functional Analysis Tools: Provides tools for identifying lncRNAs with potential functional significance based on integrated annotations and associations.

Scientific Applications:

• Disease association analysis: Enables investigation of lncRNA-disease associations using curated association data.
• Functional annotation and discovery: Supports identification of lncRNA functions and molecular signatures from integrated annotations.
• Drug–lncRNA interaction analysis: Facilitates exploration of associations between lncRNAs and drug-related information.
• CRISPR design support: Provides data relevant to CRISPR guide design associated with lncRNA targets.
• Experimental sample contextualization: Links lncRNAs to experimental sample information for contextual biological interpretation.

Methodology:

Implemented a MySQL-backed Java architecture replacing MediaWiki; an enhanced curation model enables submission and editing of annotation items; the database integrates 2,512 lncRNAs and 106,242 associations across specified domains.