LncSEA

LncSEA provides curated reference sets of human long non-coding RNAs (lncRNAs) and performs enrichment analysis to annotate lncRNA functions and regulatory associations.

Key Features:

• Comprehensive Database: Hosts over 40,000 reference lncRNA sets across 18 main categories and 66 sub-categories encompassing more than 50,000 lncRNAs.
• Data Integration: Integrates transcription factor (TF) ChIP-seq, DNase-seq, ATAC-seq and H3K27ac ChIP-seq datasets to identify lncRNA sets associated with upstream TFs and DNA regulatory elements.
• Enrichment Analysis: Performs enrichment analysis of input lncRNA lists against the reference lncRNA sets to infer functional and regulatory associations.

Scientific Applications:

• Transcriptional regulation studies: Enables linking lncRNAs to upstream TFs and regulatory elements to analyze their roles in transcriptional regulation.
• Regulatory network analysis: Supports identification of associations between lncRNAs and downstream targets or regulatory modules using curated lncRNA sets.
• Genomic and disease research: Facilitates genomic and transcriptomic investigations, including exploring lncRNA involvement in disease mechanisms.

Methodology:

Curates lncRNA sets from downstream regulatory data and upstream TFs and DNA regulatory elements by leveraging TF ChIP-seq, DNase-seq, ATAC-seq and H3K27ac ChIP-seq datasets.