lol

lol enhances Lasso inference for genomic and high-throughput molecular biology data by applying optimization methods with a matrix wrapper in R/Bioconductor.


Key Features:

  • Lasso inference enhancement: Applies methods to improve the efficiency and accuracy of Lasso (L1-penalized) regression inference.
  • Optimization methods: Incorporates various optimization methods to accelerate and stabilize Lasso estimation.
  • Matrix wrapper approach: Uses a matrix wrapper to facilitate handling and manipulation of complex data structures.
  • R and Bioconductor integration: Implements functionality within the R environment and integrates with Bioconductor workflows.
  • High-throughput data support: Targets large-scale genomic and molecular biology datasets typical of high-throughput experiments.

Scientific Applications:

  • Genomic feature selection: Enables selection of significant predictors in high-dimensional genomic datasets using Lasso techniques.
  • High-throughput analysis: Supports analysis of large-scale genomics and molecular biology data where efficient Lasso inference is required.
  • Predictor identification in genomics: Facilitates identification of relevant variables in genomic studies through improved Lasso estimation.

Methodology:

Implements Lasso regression inference using various optimization methods and a matrix wrapper within R/Bioconductor.

Topics

Collections

Details

License:
GPL-2.0
Tool Type:
command-line tool, library
Operating Systems:
Linux, Windows, Mac
Programming Languages:
R
Added:
1/17/2017
Last Updated:
11/25/2024

Operations

Publications

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods. 2015;12(2):115-121. doi:10.1038/nmeth.3252. PMID:25633503. PMCID:PMC4509590.

Documentation

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