LOLA

LOLA performs enrichment analysis of genomic region sets to interpret functional genomics and epigenomics data.

Key Features:

• Automated Enrichment Analysis: Automates testing overlaps between user-defined genomic region sets and reference databases to identify enriched region annotations.
• Integration with Reference Databases: Compares genomic region sets against large-scale reference databases to contextualize high-throughput region-based data.
• Customizable Analysis: Allows testing overlaps with public genomic range databases or user-supplied custom regions.

Scientific Applications:

• Functional Genomics and Epigenomics Interpretation: Interprets spatial relationships among genomic elements in functional genomics and epigenomics datasets.
• Identification of Regulatory Mechanisms: Aids in uncovering potential regulatory interactions by identifying significantly overlapping genomic regions.

Methodology:

Systematically tests overlaps between user-defined genomic region sets and reference datasets to perform enrichment analyses.