LongGeneDB

LongGeneDB provides a comprehensive multi-omics resource of protein-coding genes exceeding 200 kilobases to support comparative, regulatory, and evolutionary analyses of long genes.

Key Features:

• Extensive Genomic Data: Contains a curated set of 992 protein-coding long genes (>200 kb) across 15 species.
• Multi-Omics Integration: Integrates genomic conservation, histone modifications, chromatin organization, tissue-specific transcriptomes, and single-cell transcriptomes for long genes.
• Evolutionary Analysis: Analyzes the evolutionary history of gene lengths across 15 species spanning six Classes and 11 Orders.

Scientific Applications:

• Comparative Genomics: Enables cross-species comparison of long-gene conservation and length evolution.
• Gene Regulation and Chromatin Studies: Supports investigation of transcriptional and co-transcriptional processes, histone modification patterns, and chromatin organization of long genes.
• Disease Association Research: Facilitates exploration of relationships between long genes and human diseases.

Methodology:

Performed systematic analysis of publicly accessible multi-omics data to examine genomic conservation, histone modifications, chromatin organization, tissue-specific transcriptomes, and single-cell transcriptomes in long genes from the mouse genome and investigated the evolutionary history of these genes across multiple species.