Loop Catalog

Loop Catalog curates HiChIP loop calls from over 1000 distinct human and mouse samples plus 44 high-resolution Hi-C samples, providing embedded analysis modules for interpreting chromatin looping data.

Key Features:

• Comprehensive Database: The catalog spans over 4.19 million unique loops from 152 studies.
• SNP-to-Gene Linking: Links GWAS and eQTL variants to target genes through chromatin loop annotations.
• Motif Analysis: Identifies enriched sequence motifs and motif pairs from loop data.
• Regulatory Network Generation: Generates regulatory networks from chromatin looping information.
• 2D Structure Representation: Produces 2D representations of chromatin structure.

Scientific Applications:

• Variant Prioritization: Facilitates interpretation of GWAS variants through chromatin loop-based SNP-to-gene mapping.
• eQTL Interpretation: Supports understanding of expression quantitative trait loci by linking regulatory variants to genes via chromatin loops.
• Chromatin Architecture Analysis: Enables study of higher-order chromatin organization across diverse human and mouse cell types and conditions.

Methodology:

Loop calls were generated from published HiChIP datasets; specific computational methods for loop calling and analysis modules are not explicitly detailed in the sources.