LSD

LSD provides a curated repository of 1,145 senescence-associated genes (SAGs) from 21 plant species to support research into the molecular mechanisms of leaf senescence.

Key Features:

• Content scope: Contains 1,145 senescence-associated genes (SAGs) collected from 21 plant species.
• Evidence-based curation: Genes are curated based on genetic, genomic, proteomic, physiological, and other experimental evidence.
• Functional and phenotype classification: SAGs are categorized by their roles in leaf senescence and by morphological phenotypes observed in mutants.
• Annotation sources: Annotations derive from manual curation complemented by computational methods.
• Data types: Includes literature references, mutant data, phenotypic descriptions, expression profiles, miRNA interactions, orthologs, and cross-links to additional databases.
• Sequence analysis integration: Integrated with the WebLab bioinformatics analysis platform to perform sequence analyses on selected SAGs.
• Bulk sequence access: Provides sequence download for bulk analysis.

Scientific Applications:

• Systems biology: Supports systems-level analyses of senescence-related gene networks and interactions.
• Comparative genomics: Enables cross-species ortholog comparisons and comparative studies of senescence genes.
• Functional genomics: Facilitates functional inference and experimental follow-up using mutant data and phenotype annotations.
• Molecular mechanism investigation: Supports studies aimed at elucidating molecular mechanisms underlying leaf senescence.
• Large-scale sequence analyses: Enables bulk sequence analyses and integration with WebLab for high-throughput sequence processing.

Methodology:

Data were compiled via a comprehensive literature survey; genes were manually curated using genetic, genomic, proteomic, physiological, and other experimental evidence; annotations were augmented by computational methods; the database is integrated with WebLab and provides sequence download for analysis.