M3Cs

M3Cs catalogs published microRNA (miRNA) research relevant to 16 pediatric cancer diseases to consolidate evidence for clinical and preclinical investigations.

Key Features:

• Curated Collection: Aggregates 538 miRNAs from 268 clinical-domain publications and 7 miRNAs from 5 publications that span both clinical and drug domains.
• Data-driven Clinical Significance: Emphasizes clinical implications of reported miRNAs across 16 pediatric cancer diseases.
• Data-driven Human Pediatric Cell Line Models: Focuses on studies using pediatric cell line models to investigate miRNA roles in cancer biology and therapeutic response.
• Comprehensive Cell Line Data: Includes 538 miRNAs from 1,268 cell-line publications and 211 miRNAs from 177 publications intersecting with drug research.
• Development Phases: Incorporates literature mining (external database searches and rigorous screening), data extraction, curation, and annotation.
• Translational Bioinformatics Pathway: Facilitates translation of miRNA research into clinical practice and drug discovery to support hypothesis generation and policy development.

Scientific Applications:

• Clinical Significance: Aggregated miRNA evidence supports evaluation of miRNAs as biomarkers or therapeutic targets in pediatric oncology.
• Drug Discovery: Highlights miRNAs involved in drug response and intersections between cell line and drug-domain studies to inform target identification.
• Health Informatics: Provides curated miRNA evidence to inform healthcare decision-making and policy formulation related to pediatric cancer.

Methodology:

Literature mining via external database searches and rigorous screening, followed by data extraction, curation, and annotation.