MagMD

MagMD catalogs interactions between human gut microbiota, microbial enzymes, and active substances, focusing on pharmaceuticals to support analysis of microbiome-mediated drug metabolism.

Key Features:

• Extensive Interaction Records: Contains 32,678 records describing interactions among 2,146 gut microbes, 36 enzymes, and 219 substrates (primarily drugs).
• Detailed Annotations: Entries include taxonomic level of microbes, molecular form and PubChem Compound ID (PubChem Compound Database) of drugs, types of microbial secreted enzymes, and links to original research references.
• Pharmaceutical Focus: Dataset emphasizes pharmaceutical compounds and microbial biotransformation relevant to pharmacokinetics and pharmacodynamics.

Scientific Applications:

• Drug–microbiota interaction studies: Enables analysis of how specific gut microbes and enzymes modify drugs and active substances.
• Patient stratification by microbiome: Supports grouping of individuals based on microbiome-associated drug metabolism potential.
• Toxic metabolite and safety assessment: Facilitates investigation of microbial formation of toxic metabolites and implications for drug safety and efficacy.

Methodology:

MagMD leverages metagenomic sequencing data to map metabolic functions of gut microbes and their interactions with drugs and integrates these data into a database annotated with taxonomic level, molecular forms, PubChem Compound IDs, enzyme types, and literature references.